Color Doppler Ultrasound Imaging Course
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Enhance your medical skills with our Doppler Ultrasound Course! Master blood flow assessment and vascular diagnosis with expert-led training, hands-on practice, and cutting-edge techniques. Enroll now to advance your career.
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Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone.
5. Endocannabinoid Biosynthesis:
Derived from membrane phospholipids via enzymatic reactions.
Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Physiological Roles of Lipid Autocoids
1. Inflammation and Immune Response
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Distribution (somatic/autonomic)
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Function (sensory/motor)
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Introduction
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Classification of Lipid Autocoids
Lipid autocoids are broadly classified into the following categories:
1. Eicosanoids (Derived from Arachidonic Acid)
Prostaglandins (PGs)
Thromboxanes (TXs)
Leukotrienes (LTs)
Lipoxins (LXs)
2. Specialized Pro-resolving Mediators (SPMs)
Resolvins
Protectins
Maresins
3. Endocannabinoids
Anandamide (AEA)
2-Arachidonoylglycerol (2-AG)
4. Platelet-Activating Factor (PAF)
5. Sphingolipid-Derived Mediators
Sphingosine-1-Phosphate (S1P)
Ceramides
Biosynthesis of Lipid Autocoids
Lipid autocoids are derived from membrane phospholipids through enzymatic pathways:
1. Phospholipase A2 (PLA2) Activation:
PLA2 catalyzes the release of arachidonic acid (AA) from membrane phospholipids.
2. Cyclooxygenase (COX) Pathway:
Converts AA into prostaglandins and thromboxanes.
COX-1: Constitutive enzyme (housekeeping functions).
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3. Lipoxygenase (LOX) Pathway:
Converts AA into leukotrienes and lipoxins.
5-LOX: Leads to leukotrienes (inflammation, bronchoconstriction).
12-LOX & 15-LOX: Lead to lipoxins (anti-inflammatory action).
4. Cytochrome P450 (CYP) Pathway:
Converts AA into epoxyeicosatrienoic acids (EETs), which regulate vascular tone.
5. Endocannabinoid Biosynthesis:
Derived from membrane phospholipids via enzymatic reactions.
Degraded by fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL).
Physiological Roles of Lipid Autocoids
1. Inflammation and Immune Response
Prostaglandins (e.g., PGE2) modulate fever and pain.
Leukotrienes mediate allergic responses and asthma.
Lipoxins and resolvins promote resolution of inflammation.
2. Cardiovascular System
Thromboxanes (TXA2) induce platelet aggregation and vasoconstriction.
Prostacyclin (PGI2) inhibits platelet aggregation and promotes vasodilation.
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3. Pulmonary Function
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PGE2 has bronchodilatory effects.
4. Renal Function
Prostaglandins regulate glomerular filtration rate and sodium excretion.
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5. Neurotransmission and Pain
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Prostaglandins contribute to central pain sensitization.
6. Reproductive System
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Dysfunctioning of the nerve fibre can cause major acquired and inherited neurological disorders that affect both the central nervous system and the peripheral nervous system.
Physiological Properties of Nerve Fibres
Excitability: The nerve fibres are highly excitable structures that respond to several stimuli and can also generate electrical impulses.
Conductivity: The electrical impulses generated in the nerve fibres are propagated along its entire length and to different neurons, muscles and glands by synaptic connections.
Refractory Period: The nerve fibres can conduct one action potential at once, i.e., the excitability of the fibres is less during conduction and hence a new electrical impulse cannot be generated.
All or None Response: A nerve fiber translates either all of the impulse or none at all. If a stimulus is applied upto a threshold level, an action potential will be generated but increasing the strength of the stimulus will not affect the action potential.
Summation: If a sub-threshold stimulus is applied, it cannot generate an action potential. However, when multiple sub-threshold stimuli are applied in rapid succession, an action potential is generated.
Classification of Nerve Fibers
Nerve fibers are classified based on
Structure (myelinated/unmyelinated)
Distribution (somatic/autonomic)
Origin (cranial/spinal)
Function (sensory/motor)
Diameter/impulse conduction (A, B, C fibers).
They exhibit properties like excitability, conductivity, and the ability to transmit signals via electrical and chemical pathways.
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✅ 435 pre-orders (131 paid)
✅ 2 patents filed, 4 in progress
✅ Preparing for FDA 510(k)
We are currently raising $5M to scale across the U.S., EU, IL and MENA.
Contact: ceo@u-pump.com
Learn more: www.u-pump.com
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Integrity involves consistently upholding ethical standards and maintaining a strong moral compass, ensuring that actions align with core values and principles.
Honesty emphasizes transparency and truthfulness in communication and actions, fostering trust among colleagues, clients, and stakeholders.
Responsibility focuses on taking ownership of one’s actions and their consequences, fulfilling commitments, and being accountable for decisions made in a professional context.
Together, these qualities promote a positive work environment, enhance relationships, and contribute to long-term success and respect in any profession.
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Principles of GALP
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1. Data Integrity: Ensuring accurate, reliable, and tamper-proof data recording and analysis.
2. Regulatory Compliance: Adhering to national and international standards such as ISO, 21 CFR Part 11, and QCI guidelines.
3. Standardized Processes: Implementing well-defined SOPs to guide laboratory operations.
4. System Validation: Regularly verifying automated instruments and software for functionality and compliance.
5. Personnel Training: Ensuring that laboratory staff are adequately trained to operate automated systems efficiently and accurately.
6. Risk Management: Identifying and mitigating potential risks in automated workflows.
7. Continuous Improvement: Periodic reviews and updates to laboratory practices to incorporate technological advancements.
GALP Requirements
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1. Standardized Documentation: Maintaining comprehensive records of laboratory procedures and automation processes.
2. Software and Instrument Validation: Ensuring that all automated systems function as intended and comply with regulatory requirements.
3. Data Security Measures: Implementing encryption, access control, and audit trails for secure data management.
4. Regulatory Compliance: Aligning with relevant regulations such as 21 CFR Part 11, ISO standards, and QCI guidelines.
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SOPs of GALP
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3. Sample Handling: Ensuring standardized procedures for sample collection, processing, and storage.
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Training Documentation
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There is no physical contact between two neurones.
Synapse: The point at which the nerve impulse passes from the presynaptic neurone to the postsynaptic neurone.
Presynaptic Neurons: The neurons that carries action potential to the synapse.
Postsynaptic Neurons: Neurons that carries action potential away from the synapse.
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These are in close proximity to the dendrites and the cell body of the postsynaptic neurone.
The space between them is the synaptic cleft.
Synaptic knobs contain spherical membrane bound synaptic vesicles, which store a chemical (the neurotransmitter) that is released into the synaptic cleft.
Neurotransmitters are synthesised by nerve cell bodies, actively transported along the axons and stored in the synaptic vesicles.
They are released by exocytosis in response to the action potential in the presynaptic neurons and diffuse across the synaptic cleft.
They act on specific receptor sites on the postsynaptic membrane.
Their action is short lived, because immediately they have acted on the postsynaptic cell such as a muscle fibre, they are either inactivated by enzymes or taken back into the synaptic knob.
Some important drugs act by mimicking, neutralising (antagonising), or prolonging normal actions of neurotransmitters.
Neurotransmitters usually have an excitatory effect on postsynaptic receptors but they are sometimes inhibitory.
There are more than 50 neurotransmitters in the brain and spinal cord including noradrenaline (norepinephrine), adrenaline (epinephrine), dopamine, histamine, serotonin, gamma aminobutyric acid (GABA) and acetylcholine.
Other substances, such as Neuropeptides (enkephalins, endorphins and substance P) have specialised roles in, for example, transmission of pain signals.
Excitatory neurotransmitters: Acetylcholine, Norepinephrine, Dopamine (Initiate New Impulse)
Inhibitory neurotransmitters: GABA, Serotonin, Glycine (Reduces the chance of new impulse, Hyperpolarization).
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Additionally, this presentation focuses on the role of physiotherapy in managing RA. It covers various physiotherapy techniques, including exercise therapy, manual therapy, and modalities such as heat/cold therapy and TENS, which help improve joint mobility, reduce pain, and enhance overall function. It also emphasizes the importance of patient education and the need for a multidisciplinary approach to effectively manage RA.
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This presentation was uploaded with the author’s consent.
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Age and Gender
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Gen Z spends the most amount of time on social media, so the notion that social media negatively affects mental health appears to be correlated. Unfortunately, Gen Z is also the generation that’s least comfortable discussing mental health concerns with healthcare professionals. Only 40% of them state they’re comfortable discussing their issues with a professional compared to 60% of Millennials and 65% of Boomers.
Race Affects Attitudes
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- 1. Mediflick Mediflick Your favourite online courses at anytime from anywhere!
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